Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow. (November 2017)

• Record Type: Journal Article
• Authors: Rogers, Nicola J; Jeffery, Hannah C; Claire, Sunil; Lewis, David J; Zikeli, Gerald; Hodges, Nikolas J; Egginton, Stuart; Nash, Gerard B; Pikramenou, Zoe
• Is Part Of: Nanomedicine. Volume 12:Number 22(2017)
• Page Start: 2725
• Page End: 2740
• Publication Date: 2017-11
• Subjects: blood flow -- gold nanoparticles -- imaging -- luminescence -- metal probes; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0211
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow.Materials & methods: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues.Results: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle.Conclusion: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.