A centipede like thiocyanate-bridged muti-nuclear copper(I/II) complex derived from 2-(((2-(dimethylamino)ethyl)imino)methyl)-5-fluorophenol with urease inhibitory activity. Issue 5 (30th June 2022)

• Record Type: Journal Article
• Authors: Feng, Xinhui; Wu, Wenlong; Gu, Yuqing; Zhang, Li; Wang, Shiyi; Zhao, Jie; Ji, Jing; Shi, Dahua; You, Zhonglu
• Is Part Of: Journal of coordination chemistry. Volume 75:Issue 5/6(2022)
• Page Start: 720
• Page End: 728
• Publication Date: 2022-06-30
• Subjects: Schiff base -- copper(I/II) complex -- thiocyanate -- crystal structure -- urease inhibition; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2022.2062232
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A centipede like thiocyanate-bridged multi-nuclear copper(I/II) complex, [Cu2 L(CH3 OH)(NCS)3 ]n, derived from 2-(((2-(dimethylamino)ethyl)imino)methyl)-5-fluorophenol (HL), was prepared and characterized by elemental analysis, IR and UV–vis spectra, as well as single crystal X-ray diffraction. The Cu1 ion in the +2 oxidation state is coordinated by the tridentate Schiff base ligand in a square pyramidal geometry, with the other two sites occupied by one N atom of the thiocyanate ligand and one methanol O atom. The Cu2 ion in the +1 oxidation state is coordinated by one N and three S atoms from four thiocyanate ligands, forming a tetrahedral geometry. The CuI ions are linked by thiocyanate ligands to form a one-dimensional chain with [Cu I 2 ( μ 1, 3, 3 -NCS)2 ] as the repeat unit. The [Cu II L(CH3 OH)] moieties are linked to the chain through thiocyanate ligands. The complex has remarkable inhibitory activity on Jack bean urease with an IC50 value of 1.3 μmol L –1 . Graphical Abstract: UF0001