Variation in the α2A-adrenergic receptor gene and risk of gestational diabetes. (October 2017)

• Record Type: Journal Article
• Authors: Kawai, Vivian K; Levinson, Rebecca T; Adefurin, Abiodun; Kurnik, Daniel; Collier, Sarah P; Conway, Douglas; Stein, Charles Michael
• Is Part Of: Pharmacogenomics. Volume 18:Number 15(2017)
• Page Start: 1381
• Page End: 1386
• Publication Date: 2017-10
• Subjects: ADRA2A variants -- Caucasians -- gestational diabetes; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0079
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: Sympathetic activation suppresses insulin secretion via pancreatic ADRA2A. Because sympathetic activity and insulin demand increase during pregnancy, we tested the hypothesis that ADRA2A variants are associated with gestational diabetes (GDM).Patients & methods: Among Caucasian pregnant women without pre-existing diabetes, we genotyped 458 who had GDM and 1537 without GDM for seven ADRA2A variants.Results: rs1800038 (OR: 2.34; p = 0.020) and rs3750625 (OR: 1.56; p = 0.010) increased the risk of GDM, and rs11195418 decreased it (OR: 0.62; p = 0.025). The associations remained significant after adjustment for maternal age, maternal BMI, parity and a genetic risk score that included variants previously associated with Type 2 diabetes mellitus and GDM.Conclusion: ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women.