Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. (16th July 2020)

• Record Type: Journal Article
• Authors: Bravi, Francesca; Lee, Yuan‐Chin Amy; Hashibe, Mia; Boffetta, Paolo; Conway, David I.; Ferraroni, Monica; La Vecchia, Carlo; Edefonti, Valeria
• Other Names: Agudo Antonio investigator.; Ahrens Wolfgang investigator.; Benhamou Simone investigator.; Boccia Stefania investigator.; Brennan Paul investigator.; Brenner Hermann investigator.; Cadoni Gabriella investigator.; Canova Cristina investigator.; Chen Chu investigator.; Chuang Shu‐Chun investigator.; Curado Maria Paula investigator.; Dal Maso Luigino investigator.; Daudt Alexander W investigator.; D'Souza Gypsyamber investigator.; Fabianova Eleonora investigator.; Fernandez Leticia investigator.; Franceschi Silvia investigator.; Garavello Werner investigator.; Gillison Maura investigator.; Gross Neil D investigator.; Hayes Richard B investigator.; Healy Claire investigator.; Herrero Rolando investigator.; Holcatova Ivana investigator.; Kelsey Karl investigator.; Kjaerheim Kristina investigator.; Koifman Rosalina investigator.; Lagiou Pagona investigator.; Lazarus Philip investigator.; Levi Fabio investigator.; Li Guojun investigator.; Lissowska Jolanta investigator.; Luce Daniele investigator.; Macfarlane Gary J investigator.; Mates Dana investigator.; Matsuo Keitaro investigator.; McClean Michael investigator.; Menezes Ana investigator.; Menvielle Gwenn investigator.; Morgenstern Hal investigator.; Moyses Raquel A investigator.; Moysich Kirsten investigator.; Muscat Joshua investigator.; Negri Eva investigator.; Olshan Andrew F investigator.; Pandics Tamas investigator.; Polesel Jerry investigator.; Purdue Mark P investigator.; Radoï Loredana investigator.; Ramroth Heribert investigator.; Richiardi Lorenzo investigator.; Schantz Stimson investigator.; Schwartz Stephen M investigator.; Serraino Diego investigator.; Shangina Oxana investigator.; Smith Elaine investigator.; Sturgis Erich M investigator.; Świątkowska Beata investigator.; Thomson Peter investigator.; Toporcov Tatiana N investigator.; Vaughan Thomas L investigator.; Vilensky Marta investigator.; Winn Deborah M investigator.; Wunsch‐Filho Victor investigator.; Yu Guo‐Pei investigator.; Zevallos Jose P investigator.; Zhang Zuo‐Feng investigator.; Zheng Tongzhang investigator.; Znaor Ariana investigator.;
• Is Part Of: Oral diseases. Volume 27:Number 1(2021)
• Page Start: 73
• Page End: 93
• Publication Date: 2020-07-16
• Subjects: head and neck cancer -- INHANCE -- laryngeal cancer -- oral cavity cancer -- pooled analysis -- prognostic factors -- risk factors; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.13502
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract: Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.