Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. (March 2018)

• Record Type: Journal Article
• Authors: Levran, Orna; Peles, Einat; Randesi, Matthew; Correa da Rosa, Joel; Shen, Pei-Hong; Rotrosen, John; Adelson, Miriam; Kreek, Mary Jeanne
• Is Part Of: Pharmacogenomics. Volume 19:Number 4(2018)
• Page Start: 333
• Page End: 341
• Publication Date: 2018-03
• Subjects: abstinence -- CRHBP -- glucocorticoid receptor -- HPA axis -- NPY1R -- NPY5R -- stress resilience; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0179
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment.Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923).Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 ( NR3C1 ) and rs4234955 ( NPY1R / NPY5R ) were significantly associated with prolonged abstinence without agonist treatment.Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.