The prognostic value of serum and bronchoalveolar lavage levels of adiponectin in advanced non-small-cell lung cancer. (November 2017)

• Record Type: Journal Article
• Authors: Boura, Paraskevi; Grapsa, Dimitra; Loukides, Stylianos; Angelidou, Maria; Tsakanika, Konstantina; Syrigos, Nikolaos; Gkiozos, Ioannis
• Is Part Of: Lung cancer management. Volume 6:Number 2(2017)
• Page Start: 55
• Page End: 65
• Publication Date: 2017-11
• Subjects: adiponectin -- bronchoalveolar lavage -- NSCLC -- serum; Lungs -- Cancer -- Periodicals; 616.99424
• DOI: 10.2217/lmt-2016-0018
• Languages: English
• ISSNs: 1758-1966

Abstract

Aim: We aimed to explore the prognostic implications of adiponectin (APN) levels in the serum and bronchoalveolar lavage (BAL) of patients with advanced NSCLC.Materials & methods: 29 newly diagnosed patients with stage IV NSCLC were prospectively enrolled. Baseline serum and BAL levels of APN were assayed by ELISA and correlated with various clinicopathological parameters, including overall survival.Results: No statistically significant correlations were observed between the serum or BAL levels of APN and the clinicopathological parameters evaluated. The only prognostic factor identified, both by univariate and multivariate survival analyses, was performance status.Conclusion: The results of our cohort failed to reveal any prognostic significance of serum and BAL levels of APN in stage IV NSCLC.