An overview of meningiomas. (7th August 2018)

• Record Type: Journal Article
• Authors: Buerki, Robin A; Horbinski, Craig M; Kruser, Timothy; Horowitz, Peleg M; James, Charles David; Lukas, Rimas V
• Is Part Of: Future oncology. Volume 14:Number 21(2018)
• Page Start: 2161
• Page End: 2177
• Publication Date: 2018-08-07
• Subjects: chemotherapy -- imaging -- meningioma -- molecular pathology -- mutations -- radiotherapy -- stereotactic radiosurgery -- surgery -- targeted therapy -- tumor treating fields; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0006
• Languages: English
• ISSNs: 1479-6694

Abstract

Meningiomas are the most common primary intracranial tumor. Important advances are occurring in meningioma research. These are expected to accelerate, potentially leading to impactful changes on the management of meningiomas in the near and medium term. This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors. We will discuss clinical and radiographic presentation and therapeutic management. Surgery and radiotherapy, the two longstanding primary therapeutic modalities, will be discussed at length. In addition, data from prior and ongoing investigations of other treatment modalities, including systemic and targeted therapies, will be covered. This review will quickly update the reader on the contemporary management and future directions in meningiomas.