Alternative synthetic approaches for nucleotides and derivatives. (22nd June 2022)

• Record Type: Journal Article
• Authors: Appy, Lucie; Depaix, Anaïs; Bantreil, Xavier; Lamaty, Frédéric; Peyrottes, Suzanne; Roy, Béatrice
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 197:Number 5/6(2022)
• Page Start: 434
• Page End: 437
• Publication Date: 2022-06-22
• Subjects: Organophosphorus chemistry -- nucleotides -- dinucleotides -- supported synthesis -- mechanochemistry; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2021.1998050
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: We have focused our attention on alternative synthetic approaches for nucleotides and dinucleotides, that simplifies purification and/or improves sustainability. On one hand, we developed a liquid-phase synthesis using a benzene-centred tripodal support to prepare adenine nucleoside phosphoesters and methylenebisphosphonate derivatives. On the other hand, we used mechanochemistry, a technique that enables solid/solid reactions through mechanical grinding under solventless or solvent-free conditions, to get access to dinucleotides. Graphical Abstract: UF0001