Second generation of nucleotide analogues. (22nd June 2022)

• Record Type: Journal Article
• Authors: Gołębiewska, Justyna; Bartoszewicz, Agnieszka; Kalek, Marcin; Stawinski, Jacek
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 197:Number 5/6(2022)
• Page Start: 511
• Page End: 514
• Publication Date: 2022-06-22
• Subjects: Phosphorothioates -- phosphoroselenoates -- boranephosphonates -- nucleotide analogues; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2021.1989689
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: The most common type of modification of a phosphorus center is the replacement of one or two non-bridging atoms of the phosphate group with different heteroatoms (e.g., sulfur, selenium) or groups of atoms (e.g., methyl, borane). Such compounds are referred to as the first generation of nucleotide analogues. We were interested in exploring the possibility of further functionalizing of the heteroatoms present in nucleoside phosphorothioates, phosphoroselenoate or boranephosphonates to create a second generation of nucleotide analogues with hopefully new biological properties. Here we report a preliminary account of our work on introducing additional modifications on the sulfur or selenium heteroatom of nucleotide analogues. Graphical Abstract: UF0001