The role of clinical and molecular factors in low-grade gliomas: what is their impact on survival?. (25th June 2018)

• Record Type: Journal Article
• Authors: Franceschi, Enrico; Mura, Antonella; De Biase, Dario; Tallini, Giovanni; Pession, Annalisa; Foschini, Maria Pia; Danieli, Daniela; Pizzolitto, Stefano; Zunarelli, Elena; Lanza, Giovanni; Bartolini, Daniela; Silini, Enrico Maria; Visani, Michela; Di Oto, Enrico; Tosoni, Alicia; Minichillo, Santino; Lamberti, Giuseppe; Lanese, Andrea; Paccapelo, Alexandro; Bartolini, Stefania; Brandes, Alba A
• Is Part Of: Future oncology. Volume 14:Number 16(2018)
• Page Start: 1559
• Page End: 1567
• Publication Date: 2018-06-25
• Subjects: 1p19q co-deletion -- IDH 1/2 -- IDH mutation -- low-grade gliomas -- MGMT methylation -- NGS -- surgery -- treatment; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0634
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To evaluate relevance of clinical and molecular factors in adult low-grade gliomas (LGG) and to correlate with survival.Methods: We reviewed records from adult LGG patients from 1991 to 2015 who received surgery and had sufficient tissue to molecular biomarkers characterization.Results: 213 consecutive LGG patients were included: 17.4% were low-risk, according to Radiation Therapy Oncology Group (RTOG) risk assessment. IDH 1/2 mutation, 1p/19q co-deletion, MGMT methylation were found in 93, 50.8 and 65.3% of patients. Median follow-up was 98.3 months. In univariate analysis, overall survival was influenced by extent of resection (p = 0.011), IDH mutation (p < 0.001), 1p/19q co-deletion (p = 0.015) and MGMT methylation (p = 0.013). In multivariate analysis, RTOG clinical risk (p = 0.006), IDH mutation (p < 0.001) and 1p/19q co-deletion (p = 0.035) correlated with overall survival. RTOG clinical risk (p = 0.006), IDH mutation (p < 0.001) and 1p/19q co-deletion (p = 0.035) correlated with overall survival.Conclusion: Both clinical and molecular factors are essential to determine prognosis and treatment strategies.