YB-1 promotes laryngeal squamous cell carcinoma progression by inducing miR-155 expression via c-Myb. (8th March 2018)

• Record Type: Journal Article
• Authors: Zhao, Xudong; Zhang, Wei; Ji, Wenyue
• Is Part Of: Future oncology. Volume 14:Number 16(2018)
• Page Start: 1579
• Page End: 1589
• Publication Date: 2018-03-08
• Subjects: cervical metastasis -- c-Myb -- head and neck cancer -- invasion -- laryngeal cancer -- LSCC -- miR-155 -- prognosis -- proliferation -- YB-1; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0058
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: In this study, we investigated the role of Y-box binding protein-1 (YB-1), c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression.Materials & methods: Quantitative real-time PCR, western blot, MTT and Transwell were conducted to determine the expression and function of YB-1/miR-155 pathway. Univariate and multivariate analyses were used to determine the prognostic factors.Results: Expression of YB-1, c-Myb and miR-155 was higher in LSCC tissues. YB-1 promoted proliferation, invasiveness and migration of Hep-2 cells in vitro . Patients with higher YB-1 correlated with advanced T stage, poor differentiation and cervical metastasis. LSCC patients with high YB-1 expression showed poor overall survival.Conclusion: YB-1 promotes LSCC progression by increasing miR-155 levels via c-Myb and acts as a prognostic factor.