Statins use and cancer: an update. (3rd May 2018)

• Record Type: Journal Article
• Authors: Zaleska, Martyna; Mozenska, Olga; Bil, Jacek
• Is Part Of: Future oncology. Volume 14:Number 15(2018)
• Page Start: 1497
• Page End: 1509
• Publication Date: 2018-05-03
• Subjects: antitumor activity -- cancer treatment -- HMG-CoA reductase inhibitors -- mevalonate pathway -- statins; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0543
• Languages: English
• ISSNs: 1479-6694

Abstract

After initial concerns regarding the association of statins with increased incidences of cancer and elevated cancer-related mortality, there are now plenty of data on the antitumor, cytostatic and cytotoxic effectiveness of this class of drugs. Here, we present a short review of possible mechanisms of antineoplastic activity obtained from preclinical research and the influence of statins on cancer treatment. In the second part of the article, we focus on the most recent data from observational clinical trials, as well as meta-analyses regarding cancer incidence and mortality in patients treated with statins. Graphical abstract: