The clinicopathological features and prognosis of tumor MSI in East Asian colorectal cancer patients using NCI panel. (June 2018)

• Record Type: Journal Article
• Authors: Zheng, Jianmin; Huang, Bangxing; Nie, Xiu; Zhu, Yan; Han, Ningning; Li, Yan
• Is Part Of: Future oncology. Volume 14:Number 14(2018)
• Page Start: 1355
• Page End: 1364
• Publication Date: 2018-06
• Subjects: clinicopathological features -- microsatellite instability -- mismatch repair -- sporadic colorectal cancer; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0662
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To compare test results obtained from a PCR assay for the National Cancer Institute (NCI) five loci criteria for detecting microsatellite instability (MSI) with those obtained from immunohistochemistry of mismatch repair and a five-mononucleotide site amplification system in East Asian patients with colorectal cancer.Patients & methods: A total of 245 East Asian patients with colorectal cancer were studied retrospectively at our institution.Results: The consistency of the NCI panel PCR method compared with detection of mismatch repair protein expression by immunohistochemistry was 0.898. High level MSI (MSI-H) status was correlated with the Tumor, Node, Metastasis stage, tumor location site, metastasis, tumor grade, mucinous histological type and BRAF-type mutations.Conclusion: The NCI panel PCR assay has excellent sensitivity and specificity for detecting MSI in an East Asian population.