Microtechnology applied to stem cells research and development. (20th March 2018)

• Record Type: Journal Article
• Authors: Acevedo, Juan Pablo; Angelopoulos, Ioannis; van Noort, Danny; Khoury, Maroun
• Is Part Of: Regenerative medicine. Volume 13:Number 2(2018)
• Page Start: 233
• Page End: 248
• Publication Date: 2018-03-20
• Subjects: cancer -- differentiation -- microfabrication -- microfluidics -- microtechnology -- regenerative medicine -- stem cells -- translational medicine; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme-2017-0123
• Languages: English
• ISSNs: 1746-0751

Abstract

Microfabrication and microfluidics contribute to the research of cellular functions of cells and their interaction with their environment. Previously, it has been shown that microfluidics can contribute to the isolation, selection, characterization and migration of cells. This review aims to provide stem cell researchers with a toolkit of microtechnology (mT) instruments for elucidating complex stem cells functions which are challenging to decipher with traditional assays and animal models. These microdevices are able to investigate about the differentiation and niche interaction, stem cells transcriptomics, therapeutic functions and the capture of their secreted microvesicles. In conclusion, microtechnology will allow a more realistic assessment of stem cells properties, driving and accelerating the translation of regenerative medicine approaches to the clinic.