Bisabolane sesquiterpenes from Clausena sanki with their potential anti-inflammatory activities. Issue 24 (16th December 2020)

• Record Type: Journal Article
• Authors: Hu, Shi; Ma, Yan-Lei; Guo, Jia-Ming; Wen, Qing; Yan, Gui; Yang, Shuo; Fu, Yan-Hui; Liu, Yan-Ping
• Is Part Of: Natural product research. Volume 34:Issue 24(2020)
• Page Start: 3499
• Page End: 3505
• Publication Date: 2020-12-16
• Subjects: Clausena sanki -- sesquiterpenes -- clausemargic A -- anti-inflammatory activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1582042
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The investigation on the stems and leaves of Clausena sanki led to the isolation of a previously undescribed bisabolane sesquiterpene, clausemargic A (1 ), together with six known analogues (2 –7 ). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2 –7 ) were isolated from C. sanki for the first time. All isolated compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro . Compounds 1 –7 showed significant inhibitory activities with IC50 values comparable to that of hydrocortisone. Graphical Abstract: