Association between circulating oxidized low‐density lipoprotein and atherosclerotic cardiovascular disease. Issue 2 (25th June 2017)

• Record Type: Journal Article
• Authors: Gao, Shen; Liu, Jing
• Is Part Of: Chronic diseases and translational medicine. Volume 3:Issue 2(2017)
• Page Start: 89
• Page End: 94
• Publication Date: 2017-06-25
• Subjects: Oxidized low density lipoprotein -- Atherosclerosis -- Cardiovascular disease -- Subclinical atherosclerosis -- Review; Chronic diseases -- Periodicals; Medicine -- Research -- Periodicals; Chronic diseases; Medicine -- Research; Chronic Disease; Translational Medical Research; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.044
• DOI: 10.1016/j.cdtm.2017.02.008
• Languages: English
• ISSNs: 2095-882X

Abstract

Abstract: Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low‐density lipoprotein (ox‐LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox‐LDL, the methods of measuring ox‐LDL in the circulation, effect of medical therapy and life‐style modification on ox‐LDL level, and the association between circulating ox‐LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.