Evaluation of IgG4 levels as a fibrosis marker on disease activity in the course of hepatitis B infection. (21st May 2018)

• Record Type: Journal Article
• Authors: Karaahmet, Fatih; Hamamci, Mevlut; Akinci, Hakan; Yuksel, Ilhami; Sahingoz, Seyda; Kılıncalp, Serta
• Is Part Of: Future virology. Volume 13:Number 6(2018)
• Page Start: 385
• Page End: 390
• Publication Date: 2018-05-21
• Subjects: autoimmunity -- disease activity -- enhanced infectivity -- fibrosis stage hepatitis B infection -- IgG4 -- liver fibrosis -- noninvasive fibrosis marker -- viral replication; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2018-0012
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: Understanding immunopathogenesis of hepatitis-B virus (HBV) infection is pivotal in the management of complications. The aim of the study is to investigate the association of IgG4 levels with the liver fibrosis.Methods: Histological evaluation of the liver biopsy and laboratory analyses including IgG4 were performed.Results: A total of 130 patients fulfilling the criteria for a diagnosis of HBV infection were enrolled in the study. Of these patients, 14 had HBeAg positive and 116 had HBeAg negative HBV infection. In HBeAg-positive patients serum IgG4 levels were significantly higher than HBeAg-negative patients (p = 0.038).Conclusion: There is an association of IgG4 level and higher rates of viral replication and enhanced infectivity.