Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial. (March 2018)

• Record Type: Journal Article
• Authors: Chen, Leon; Aria, Alexander B; Silapunt, Sirunya; Lee, Heng-Huan; Migden, Michael R
• Is Part Of: Future oncology. Volume 14:Number 6(2018)
• Page Start: 515
• Page End: 525
• Publication Date: 2018-03
• Subjects: basal cell carcinoma -- BOLT -- hedgehog pathway inhibitor -- HPI -- laBCC -- locally advanced basal cell carcinoma -- mBCC -- metastatic basal cell carcinoma -- sonidegib; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0457
• Languages: English
• ISSNs: 1479-6694

Abstract

Sonidegib, a hedgehog pathway inhibitor, was approved by the US FDA for the treatment of locally advanced basal cell carcinoma which cannot be readily treated with surgery or radiotherapy. The pharmacology and pharmacokinetics of sonidegib will be discussed in this review. Additionally, an in-depth analysis of the BOLT trial and data from the 30-month update will be included. This will serve as an update to a previously published article which reported the 12-month update of the BOLT trial.