Facial diplegia with paresthesia associated with anti-GD1a antibodies. Issue 3 (4th May 2022)

• Record Type: Journal Article
• Authors: Strawbridge, Jason; Fu, Katherine A.; Chan, Joy; Flavin, William; Cohen, Joss; Keselman, Inna; Shieh, Perry
• Is Part Of: Proceedings. Volume 35:Issue 3(2022)
• Page Start: 387
• Page End: 388
• Publication Date: 2022-05-04
• Subjects: Anti-ganglioside antibodies -- demyelinating disease -- facial diplegia -- Guillain-Barré syndrome -- peripheral neuropathy -- polyneuropathy; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2022.2043679
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: A 26-year-old previously healthy man presented with progressive facial diplegia and sensory deficits to pinprick in a stocking-glove distribution. Lumbar puncture revealed cytoalbuminologic dissociation, and a nerve conduction study of the right facial nerve demonstrated a proximal demyelinating process. He was started on intravenous immunoglobulin given concern for a Guillain-Barré syndrome variant, and his symptoms improved over several days. This case illustrates the clinical features of facial diplegia with paresthesias, a rare variant of Guillain-Barré syndrome. Unlike most reported cases of facial diplegia with paresthesias that have demonstrated positive anti-ganglioside M2 antibodies, this case is unique given the positivity of anti-ganglioside D1a IgG/IgM antibodies.