18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Tang, Songhan; Dou, Xiaofeng; Zhang, Ying
• Is Part Of: Prion. Volume 16:Issue 1(2022)
• Page Start: 91
• Page End: 94
• Publication Date: 2022-12-31
• Subjects: DAT PET/CT -- sporadic Creutzfeldt-Jakob disease -- parkinsonism; Protein folding -- Periodicals; Prions -- Periodicals; Proteins -- Biotechnology -- Periodicals; 572.633
• DOI: 10.1080/19336896.2022.2093078
• Languages: English
• ISSNs: 1933-6896

Abstract

ABSTRACT: Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD.