Comprehensive characterization of differentially expressed genes in thyroid cancer. (October 2017)

• Record Type: Journal Article
• Authors: Wang, Jian; Chi, Shumei; Huang, Zhongke; Ye, Xiaojuan; Shi, Guohua; Chen, Dongfang; Lou, Cen
• Is Part Of: Future oncology. Volume 13:Number 24(2017)
• Page Start: 2159
• Page End: 2169
• Publication Date: 2017-10
• Subjects: differentially expressed genes -- GO ontology -- KEGG pathways -- protein–protein interaction network -- thyroid cancer; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0168
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To explore the patterns of gene expression and functionally characterize the differentially expressed genes (DEGs) in thyroid cancer.Methods: DEGs were determined between 57 paired thyroid cancer and noncancerous tissues using DESeq2. Subsequently, the main functions of the DEGs were studied by a variety of analyses.Results: We identified a cohort of 752 upregulated and 309 downregulated DEGs in thyroid cancer. Several hub DEGs were found in the protein–protein interaction networks. We also revealed a set of DEGs that were dysmethylated, involved in copy number variations and associated with clinical features in thyroid cancer.Conclusion: These results provide some novel findings on DEGs in thyroid cancer, which will be useful to guide further investigation and target therapy for this disease.