The expression profile and clinicopathological significance of Notch1 in patients with colorectal cancer: a meta-analysis. (October 2017)

• Record Type: Journal Article
• Authors: Li, Ganxiong; Zhou, Zheng; Zhou, Hongrun; Zhao, Lili; Chen, Dongdong; Chen, Hongzhi; Zou, Hong; Qi, Yan; Jia, Wei; Pang, Lijuan
• Is Part Of: Future oncology. Volume 13:Number 23(2017)
• Page Start: 2103
• Page End: 2118
• Publication Date: 2017-10
• Subjects: biomarker -- colorectal cancer -- meta-analysis -- Notch 1; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0178
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: This meta-analysis was conducted to evaluate the clinicopathological significance of Notch1 expression in patients with colorectal cancer (CRC).Methods: Available articles were searched from diverse databases, and the meta-analysis was done by using Stata 12.0 software.Results: Thirteen studies were included in this analysis (3401 samples). The Notch1 expression in CRC tissues was significantly higher than that in normal tissues statistically (OR: 15.46; 95% CI: 8.11–29.45; p = 0.003), and were associated with lymph node metastasis, tumor stage, depth of infiltration and histological differentiation.Discussion: There is a close relationship between higher Notch1 expression in CRC. Notch1 may be involved in tumor progression, invasion and metastasis with CRC.Conclusion: Notch1 overexpression in CRC suggested aggressive biological behaviors and thus implying that Notch1 may be a useful biomarker in CRCs.