Aberrant expression of PlncRNA-1 and TUG1: potential biomarkers for gastric cancer diagnosis and clinically monitoring cancer progression. (December 2017)

• Record Type: Journal Article
• Authors: Baratieh, Zohreh; Khalaj, Zahra; Honardoost, Mohammad Amin; Emadi-Baygi, Modjtaba; Khanahmad, Hossein; Salehi, Mansoor; Nikpour, Parvaneh
• Is Part Of: Biomarkers in medicine. Volume 11:Number 12(2017)
• Page Start: 1077
• Page End: 1090
• Publication Date: 2017-12
• Subjects: FAM83H-AS1 -- gastric cancer -- gene expression -- PlncRNA-1 -- TUG1; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2017-0090
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression.Patients & methods: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database.Results: Expression of PlncRNA-1 and TUG1 were significantly upregulated in GC tumoral tissues, and significantly correlated with clinicopathological characters. However, FAM83H-AS1 showed no consistently differential expression. The expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues.Conclusion: In conclusion, PlncRNA-1 and TUG1 genes may play a critical role in GC progression and may serve as potential diagnostic biomarkers in GC patients.