Effect of Oral Versus Intramuscular Vitamin D Replacement on Oxidative Stress and Outcomes in Traumatic Mechanical Ventilated Patients Admitted to Intensive Care Unit. (5th September 2019)

• Record Type: Journal Article
• Authors: Hasanloei, Mohammad Amin Valizade; Rahimlou, Mehran; Eivazloo, Afsoon; Sane, Shahryar; Ayremlou, Parvin; Hashemi, Reza
• Is Part Of: Nutrition in clinical practice. Volume 35:Number 3(2020)
• Page Start: 548
• Page End: 558
• Publication Date: 2019-09-05
• Subjects: cholecalciferol -- critical illness -- intensive care units -- mechanical ventilation -- trauma -- vitamin D; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1002/ncp.10404
• Languages: English
• ISSNs: 0884-5336

Abstract

Abstract: Background: This study aimed to evaluate the safety and efficacy of 2 forms of vitamin D supplementation on oxidative stress and weaning from the ventilator in patients with traumatic injury and vitamin D deficiency. Methods: Seventy‐two patients were randomly divided into 3 groups: receiving 50, 000 IU pearl cholecalciferol daily for 6 days, 1 intramuscular injection of 300, 000 IU of cholecalciferol, or a control group that did not receive any supplement. Duration of mechanical ventilation, body composition, and biochemical biomarkers were measured before and after the intervention. Result: At the end of the study, the mean serum 25(OH)D increased in the intervention groups compared with the control group ( P < .05). The interleukin 6, erythrocyte sedimentation rate, C‐reactive protein levels, Sequential Organ Failure Assessment score, duration of mechanical ventilation, and length of intensive care unit admission significantly decreased; however, total antioxidant capacity concentration did not differ significantly between the 2 intervention groups. Among the body composition variables, extracellular water ratio changes were statically different in oral vitamin D group compared with the control group ( P = .001). No side effects were reported with the supplements. Conclusions: Vitamin D administration improved clinical signs and biochemical biomarkers in a small group of patients with traumatic injury. Well‐designed multicenter clinical studies with longer intervention duration are necessary for this field.