Clinical Effects of a Pectin‐Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial. (13th October 2019)

• Record Type: Journal Article
• Authors: Maruyama, Michio; Goshi, Satoshi; Kashima, Yasushige; Mizuhara, Akihiro; Higashiguchi, Takashi
• Is Part Of: Nutrition in clinical practice. Volume 35:Number 3(2020)
• Page Start: 464
• Page End: 470
• Publication Date: 2019-10-13
• Subjects: diarrhea -- enteral formulas -- enteral nutrition -- pectins; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1002/ncp.10392
• Languages: English
• ISSNs: 0884-5336

Abstract

Abstract: Background: A pectin‐containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group ( P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group ( P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN‐related events, especially diarrhea, than SPF is.