Preoperative to postoperative change in neutrophil-to-lymphocyte ratio predict survival in colorectal cancer patients. (May 2018)

• Record Type: Journal Article
• Authors: Guo, Dong; Han, Anqin; Jing, Wang; Chen, Dawei; Jin, Feng; Li, Minghuan; Kong, Li; Yu, Jinming
• Is Part Of: Future oncology. Volume 14:Number 12(2018)
• Page Start: 1187
• Page End: 1196
• Publication Date: 2018-05
• Subjects: colorectal cancer -- neutrophil-to-lymphocyte ratio -- prognosis -- surgery -- survival; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0659
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To evaluate the prognostic value of preoperative to postoperative neutrophil-to-lymphocyte ratio changes (ΔNLR) in patients undergoing surgical resection for colorectal cancer.Patients & methods: Data of 135 such patients managed at the Shandong Cancer Hospital and Institute were retrospectively analyzed. Clinicopathologic factors, overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan–Meier curves and Cox regression models.Results: In the multivariate analysis, preoperative NLR (p = 0.002) and ΔNLR (p = 0.037) independently predicted OS, but preoperative NLR (p = 0.141) and ΔNLR (p = 0.297) were not significant prognosticators for DFS.Conclusion: Our results demonstrated the prognostic value of the ΔNLR in predicting OS in patients undergoing surgical resection for colorectal cancer. However, ΔNLR could not predict DFS.