Cytotoxic gelsedine-type indole alkaloids from Gelsemium elegans. Issue 12 (1st December 2020)

• Record Type: Journal Article
• Authors: Xue, Qiang; Hu, Jiang; Liu, Xian-Chen; Gu, Jun
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 12(2020)
• Page Start: 1138
• Page End: 1144
• Publication Date: 2020-12-01
• Subjects: Gelsemium elegans -- Loganiaceae -- indole alkaloids -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1694008
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A chemical investigation on the 95% ethanol extract of the aerial part of Gelsemium elegans resulted in the isolation of three new gelsedine-type indole alkaloids, 14 β -hydroxygelselenidine (1 ), 11-methoxygelseziridine (2 ), and 14 β -hydroxygelsedethenine (3 ). Structural elucidation of all the compounds was accomplished by spectral methods such as 1 D and 2 D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against five human non-small-cell lung cancer cell lines. Consequently, alkaloid 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 8.3 to 9.8 μM.