Nature-derived microbiota exposure as a novel immunomodulatory approach. (17th May 2018)

• Record Type: Journal Article
• Authors: Nurminen, Noora; Lin, Jake; Grönroos, Mira; Puhakka, Riikka; Kramna, Lenka; Vari, Heli K; Viskari, Hanna; Oikarinen, Sami; Roslund, Marja; Parajuli, Anirudra; Tyni, Iiris; Cinek, Ondrej; Laitinen, Olli; Hyöty, Heikki; Sinkkonen, Aki
• Is Part Of: Future microbiology. Volume 13:Number 7(2018)
• Page Start: 737
• Page End: 744
• Publication Date: 2018-05-17
• Subjects: 16s rRNA -- biodiversity hypothesis -- immune-mediated diseases -- immune modulation -- microbial diversity -- microbiome; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2017-0286
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material.Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material.Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity.Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.