Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Lee, Hsiang-Ping; Wang, Shih-Wei; Wu, Yang-Chang; Lin, Liang-Wei; Tsai, Fuu-Jen; Yang, Jai-Sing; Li, Te-Mao; Tang, Chih-Hsin
• Is Part Of: Food and agricultural immunology. Volume 31:Issue 1(2020)
• Page Start: 193
• Page End: 204
• Publication Date: 2020-01-01
• Subjects: Soya-cerebroside -- endothelial progenitor cells -- angiogenesis -- VEGF; Immunochemistry -- Periodicals; Food -- Analysis -- Periodicals; Immunoassay -- Periodicals; 616.079
• DOI: 10.1080/09540105.2020.1713055
• Languages: English
• ISSNs: 0954-0105

Abstract

ABSTRACT: Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pathological states. Soya-cerebroside, an extract from Cordyceps militaris, reduces synovial inflammation and prevents cartilage damage in an osteoarthritis model. However, the role of soya-cerebroside in VEGF-regulated EPC angiogenesis is uncertain. Records from the Oncomine database demonstrate higher levels of VEGF in cancerous tissue compared with normal tissue. This study describes VEGF-induced promotion of EPC-associated angiogenesis in vivo and how the treatment of EPCs with soya-cerebroside inhibited VEGF-facilitated migration and tube formation. The study evidence shows that the c-Src, FAK and Runx2 signalling pathways are involved in the inhibitory effects of soya-cerebroside. This novel agent may therefore be used to inhibit EPC-associated angiogenesis.