The virulence of Legionella pneumophila is positively correlated with its ability to stimulate NF-κB activation. (September 2018)

• Record Type: Journal Article
• Authors: Wang, Haoyu; Lu, Jiao; Li, Kaili; Ren, Hongyu; Shi, Yi; Qin, Tian; Duan, Xuefeng; Fang, Min
• Is Part Of: Future microbiology. Volume 13:Number 11(2018)
• Page Start: 1247
• Page End: 1259
• Publication Date: 2018-09
• Subjects: Legionella pneumophila -- NF-κB signaling pathway -- virulence -- host immune responses -- infectious disease -- innate immunity; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2018-0051
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: Our work is to study the correlation between the virulence of different Legionella pneumophila in mouse model and its ability to activate NF-κB signaling pathway in vitro .Materials & methods: We measured the abilities of different strains of L. pneumophila to induce the activation of NF-κB signaling pathway in vitro . By using A/J mice, we also detected the virulence of different strains in vivo .Results & conclusion: We demonstrated that different strains of L. pneumophila induce different levels of activation to NF-κB signaling pathway in vitro . We also found that L. pneumophila strain induced higher NF-κB activation in vitro showed more severe weight losses, higher mortality, more severe lung inflammation and higher levels of serum cytokines production in mice. Graphical Abstract: