Comparative genomics of type 1 IncC plasmids from China. (December 2017)

• Record Type: Journal Article
• Authors: Ma, Lizhi; Yin, Zhe; Zhang, Defu; Zhan, Zhe; Wang, Qian; Duan, Xiongbo; Gao, Huixia; Liang, Quanhui; Zhao, Yuzong; Feng, Jiao; Zhao, Yachao; Tong, Yigang; Dai, Erhei; Zhou, Dongsheng
• Is Part Of: Future microbiology. Volume 12:Number 16(2017)
• Page Start: 1511
• Page End: 1522
• Publication Date: 2017-12
• Subjects: Citrobacter freundii -- multidrug resistance -- p112298-tetA -- type 1 IncC plasmid; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2017-0072
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: This study dealt with genomic characterization of type 1 IncC resistance plasmids, capable of spreading across taxonomic borders, from China.Materials & methods: p112298-tetA was sequenced and compared with type 1 IncC reference plasmid pR148 and two available sequenced type 1 IncC plasmids pHS36-NDM and pVAS3-1 from China.Results: These plasmids contained one or more exogenous resistance islands, which included the ARI-A islands, the ARI-B islands, the IS Ecp1 -blaCMY units and the bla KPC-2 region and were inserted at various sites in the IncC backbone and thus represented three distinct lineages.Conclusion: Complex rearrangement and homologous recombination events have occurred during evolution of p112298-tetA, making it significantly differ modularly from the other three plasmids with respect to both plasmid backbone and exogenous resistance regions.