Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women. (October 2017)

• Record Type: Journal Article
• Authors: Boyne, Devon J; Friedenreich, Christine M; McIntyre, John B; Courneya, Kerry S; King, Will D
• Is Part Of: Epigenomics. Volume 9:Number 10(2017)
• Page Start: 1267
• Page End: 1277
• Publication Date: 2017-10
• Subjects: adiposity -- Alu -- body fat -- DNA methylation -- LINE-1 -- postmenopausal -- repetitive elements; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0047
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To describe the association between adiposity and repetitive element DNA methylation in healthy postmenopausal women.Patients & methods: A cross-sectional study was conducted using baseline information from 289 women who participated in the Alberta Physical Activity and Breast Cancer Prevention trial.Results: After adjusting for important confounders, long interspersed nuclear element-1 methylation was positively associated with intra-abdominal fat area (p = 0.03), body fat percent (p = 0.048), fat mass (p = 0.01), waist circumference (p = 0.03), hip circumference (p = 0.001), BMI (p = 0.03), current weight (p = 0.002), weight at age 20 (p = 0.02) and adulthood weight gain (p = 0.03). No significant associations were found between any of the adiposity measures and Alu methylation.Conclusion: Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.