The effect of inflammation-related lifestyle exposures and interactions with gene variants on long interspersed nuclear element-1 DNA methylation. (11th June 2018)

• Record Type: Journal Article
• Authors: Gogna, Priyanka; O'Sullivan, Dylan E; King, Will D
• Is Part Of: Epigenomics. Volume 10:Number 6(2018)
• Page Start: 785
• Page End: 796
• Publication Date: 2018-06-11
• Subjects: BMI -- DNA methylation -- gene variants -- inflammation -- lifestyle factors -- LINE-1 -- NSAID use -- one-carbon metabolism -- physical activity; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0164
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To examine the relationship between inflammation-related lifestyle factors and long interspersed nuclear element-1 (LINE-1) DNA methylation, and test for interaction by gene variants involved in one-carbon metabolism.Patients & methods: The study population consisted of 280 individuals undergoing colonoscopy screening. Multivariable linear regression was employed to examine associations of physical activity, BMI and NSAID use with LINE-1 DNA methylation and interactions with MTR and MTHFR gene variants.Results: The highest quartile of physical activity compared with the lowest was associated with higher LINE-1 DNA methylation (p = 0.005). Long-term NSAID use and a normal BMI were associated with increased LINE-1 DNA methylation among individuals with the variant MTR allele (p = 0.02; p = 0.03).Conclusion: This study provides evidence that inflammation-related exposures may influence LINE-1 DNA methylation.