Integrated analysis of methylome, transcriptome and miRNAome of three pig breeds. (25th April 2018)

• Record Type: Journal Article
• Authors: Fu, Yuhua; Li, Jingxuan; Tang, Qianzi; Zou, Cheng; Shen, Linyuan; Jin, Long; Li, Cencen; Fang, Chengchi; Liu, Rui; Li, Mingzhou; Zhao, Shuhong; Li, Changchun
• Is Part Of: Epigenomics. Volume 10:Number 5(2018)
• Page Start: 597
• Page End: 612
• Publication Date: 2018-04-25
• Subjects: important economic trait -- methylome -- transcriptome; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0087
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: Integrated analysis of methylome and transcriptome may help understand the molecular basis of the different breeds with different traits of commercial interest.Materials & methods: We obtained the first genome-wide methylome with single-base resolution, miRNAome and transcriptome from three swine breeds.Results: We displayed the landscape of the three omics in the whole-genome level. Integrated outcomes of methylome with genetic selection, miRNAome and transcriptome are also provided. Finally, we identified 11 candidate differentially methylated genes associated with phenotype variance in pigs.Conclusion: DNA methylation not only suppresses transcriptome but also miRNAome. The different -omics data have complicated interaction in directly or indirectly and exhibited close relations with the distinct phenotypic traits of growth, disease resistance and energy metabolism.