Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment. (January 2018)

• Record Type: Journal Article
• Authors: Arpón, Ana; Milagro, Fermín I; Laja, Ana; Segura, Víctor; de Pipaón, Miguel Sáenz; Riezu-Boj, José-Ignacio; Alfredo Martínez, J
• Is Part Of: Epigenomics. Volume 10:Number 1(2018)
• Page Start: 91
• Page End: 103
• Publication Date: 2018-01
• Subjects: Bayley scale -- epigenetics -- full-term newborns -- peripheral white blood cells -- prematurity -- preterm newborns -- SLC6A3; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0082
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells.Patients & methods: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months.Results: From all the statistically significant CpGs, methylation levels of cg00997378 ( SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors.Conclusion: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.