Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer. (August 2022)

• Record Type: Journal Article
• Authors: Pinato, David J.; Ferrante, Daniela; Aguilar-Company, Juan; Bower, Mark; Salazar, Ramon; Mirallas, Oriol; Sureda, Anna; Bertuzzi, Alexia; Brunet, Joan; Lambertini, Matteo; Maluquer, Clara; Pedrazzoli, Paolo; Biello, Federica; Lee, Alvin J.X.; Sng, Christopher C.T.; Liñan, Raquel; Rossi, Sabrina; Carmona-García, M.Carmen; Sharkey, Rachel; Eremiev, Simeon; Rizzo, Gianpiero; Bain, Hamish DC.; Yu, Tamara; Cruz, Claudia A.; Perachino, Marta; Saoudi-Gonzalez, Nadia; Fort-Culillas, Roser; Doonga, Kris; Fox, Laura; Roldán, Elisa; Zoratto, Federica; Gaidano, Gianluca; Ruiz-Camps, Isabel; Bruna, Riccardo; Patriarca, Andrea; Shawe-Taylor, Marianne; Fusco, Vittorio; Martinez-Vila, Clara; Berardi, Rossana; Filetti, Marco; Mazzoni, Francesca; Santoro, Armando; Delfanti, Sara; Parisi, Alessandro; Queirolo, Paola; Aujayeb, Avinash; Rimassa, Lorenza; Prat, Aleix; Tabernero, Josep; Gennari, Alessandra; Cortellini, Alessio; Pinato, David J.; Evans, Joanne S.; Swallow, Judith; Cortellini, Alessio; Hanbury, Georgina; Chung, Chris; Patel, Meera; Dettorre, Gino; Ottaviani, Diego; Chowdhury, Amani; Lee, Alvin JX.; Sng, Christopher CT.; Yu, Tamara; Shawe-Taylor, Marianne; Bain, Hamish DC.; Sinclair, Alasdair; Cooper, Lee; Rogers, Lucy; Belessiotis, Katherine; Murphy, Cian; Bawany, Samira; Khalique, Saira; Andaleeb, Ramis; Bower, Mark; Dalla Pria, Alessia; Sharkey, Rachel; Newsom-Davis, Thomas; Dolly, Saorise; Sita-Lumsde, Ailsa; Apthorp, Eleanor; Jones, Eleanor; Van Hemelrijck, Mieke; Moss, Charlotte; Russell, Beth; Apthorp, Eleanor; Diamantis, Nikolaos; Mukherjee, Uma; Townsend, Sarah; Jackson, Amanda; Loizidou, Angela; Piccart, Martine; Prat, Aleix; Cruz, Claudia A.; Reyes, Roxana; Segui, Elia; Marco-Hernández, Javier; Viladot, Margarita; Tabernero, Josep; Aguilar-Company, Juan; Ruiz-Camps, Isabel; Fox, Laura; Garcia Illescas, David; Saoudi, Nadia; Mirallas, Oriol; Roldán, Elisa; Brunet, Joan; Carmona Garcia, MCarmen; Fort-Culillas, Robert; Liñan, Raquel; Harbeck, Nadia; Wuerstlein, Rachel; Henze, Franziska; Mahner, Sven; Mesia, Ricard; Felip, Eudald; Plaja, Andrea; Cucurull, Marc; Salazar, Ramon; Sureda, Anna; Maluquer, Clara; Gennari, Alessandra; Biello, Federica; D'Avanzo, Francesca; Gaidano, Gianluca; Bruna, Riccardo; Patriarca, Andrea; Ferrante, Daniela; Scotti, Lorenza; Krengly, Marco; Pedrazzoli, Paolo; Rizzo, Gianpiero; Bertuzzi, Alexia; Rossi, Sabrina; Marrari, Andrea; Santoro, Armando; Rimassa, Lorenza; Grosso, Federica; Fusco, Vittorio; Delfanti, Sara; Maconi, Antonio; Betti, Marta; Vincenzi, Bruno; Tonini, Giuseppe; Zambelli, Alberto; Tondini, Carlo; Fotia, Vittoria; Chiudinelli, Lorenzo; Franchi, Michela; Libertini, Michela; Bertulli, Rossella; Provenzano, Salvatore; Generali, Daniele; Grisanti, Salvatore; Baggi, Alice; Tovazzi, Valeria; Ficorella, Corrado; Porzio, Giampiero; Parisi, Alessandro; Queirolo, Paola; Saponara, Maristella; Giusti, Raffaele; Filetti, Marco; Mazzoni, Francesca; Zoratto, Federica; Tucci, Marco; Berardi, Rossana; Cantini, Luca; Paoloni, Francesco; Guida, Annalisa; Bracarda, Sergio; Martinez-Vila, Clara; Iglesias, Maria; Sanchez de Torre, Ana; Lambertini, Matteo; Perachino, Marta; Pommeret, Fanny; Colomba, Emeline;
• Is Part Of: European journal of cancer. Volume 171(2022)
• Page Start: 64
• Page End: 74
• Publication Date: 2022-08
• Subjects: COVID-19 -- SARS-CoV-2 -- Vaccines -- Prevention -- Cancer -- Clinical efficacy; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2022.04.036
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Background: Although SARS-CoV-2 vaccines immunogenicity in patients with cancer has been investigated, whether they can significantly improve the severity of COVID-19 in this specific population is undefined. Methods: Capitalizing on OnCovid (NCT04393974) registry data we reported COVID-19 mortality and proxies of COVID-19 morbidity, including post-COVID-19 outcomes, according to the vaccination status of the included patients. Results: 2090 eligible patients diagnosed with COVID-19 between 02/2020 and 11/2021 were included, of whom 1930 (92.3%) unvaccinated, 91 (4.4%) fully vaccinated and 69 (3.3%) partially vaccinated. With the exception of a higher prevalence of patients from the UK (p = 0.0003) and receiving systemic anticancer therapy at COVID-19 diagnosis (p = 0.0082) among fully vaccinated patients, no demographics/oncological features were associated with vaccination status. The 14-days case fatality rate (CFR) (5.5% vs 20.7%, p = 0.0004) and the 28-days CFR (13.2% vs 27.4%, p = 0.0028) demonstrated a significant improvement for fully vaccinated patients in comparison with unvaccinated patients. The receipt of prior full vaccination was also associated with reduced symptomatic COVID-19 (79.1% vs 88.5%, p = 0.0070), need of COVID-19 oriented therapy (34.9% vs 63.2%, p < 0.0001), complications from COVID-19 (28.6% vs 39.4%, p = 0.0379), hospitalizations due to COVID-19 (42.2% vs 52.5%, p = 0.0007) and oxygen therapy requirement (35.7% vs 52%, p = 0.0036). Following Inverse Probability Treatment Weighting (IPTW) procedure no statistically significant difference according to the vaccination status was confirmed; however, all COVID-19 related outcomes were concordantly in favour of full vaccination. Among the 1228 (58.8%) patients who underwent a formal reassessment at participating centres after COVID-19 resolution, fully vaccinated patients experienced less sequelae than unvaccinated patients (6.7% vs 17.2%, p = 0.0320). Conclusions: This analysis provides initial evidence in support of the beneficial effect of SARS-CoV-2 vaccines against morbidity and mortality from COVID-19 in patients with cancer. Highlights: Immunogenicity of SARS-CoV-2 vaccines in patients with cancer has been investigated. There is a need for evidence of SARS-CoV-2 vaccines' efficacy from large populations. In this analysis, vaccinated patients experienced improved COVID-19 outcomes. SARS-CoV-2 vaccines are effective in reducing severe COVID-19 in patients with cancer.