Encapsulation of bioactives within electrosprayed κ-carrageenan nanoparticles. (15th October 2022)

• Record Type: Journal Article
• Authors: Fani, Niloofar; Enayati, M.H.; Rostamabadi, Hadis; Falsafi, Seid Reza
• Is Part Of: Carbohydrate polymers. Volume 294(2022)
• Publication Date: 2022-10-15
• Subjects: d-limonene (PubChem CID: 440917) -- κ-carrageenan (PubChem CID: 11966249) -- Tween 20 (PubChem CID: 443314) -- Sodium chloride (PubChem CID: 5234) -- Hexane (PubChem CID: 8058) -- Hydrochloric acid (PubChem CID: 313) -- Sodium hydroxide (PubChem CID: 14798) -- Phosphate buffer (PubChem CID: 24203); κ-Carrageenan -- d-limonene -- Electrospraying -- κ-Carrageenan nanoparticles -- Sensitive bioactives -- Controlled release; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119761
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: In this study, an electrospray synthesis approach was utilized in which a solution mixture of a sensitive bioactive agent, d -limonene (DL, R-(+)-Limonene), and a nature-inspired polymer, κ-carrageenan (κC) was applied to design DL-κC nanoparticles (NPs) in a one step process. The engineered DL-κC NPs displayed spherical morphology and the maximum encapsulation efficiency of NPs was about 97 % by altering the mass ratio of DL to κC. The developed DL-κC NPs showed a pH-dependent release manner in vitro. Both photostability and thermostability of DL were promoted by increasing the κC concentration, and >85 % of the original DL could be preserved following 120 min of UV-light exposure in the NPs with 0.5 % κC. The results demonstrated that electrosprayed κC NPs are promising candidates for the design of high-loading pH-sensitive NPs for encapsulation of highly sensitive bioactive agents. Graphical abstract: Unlabelled Image