Exploring in vivo multiple sclerosis brain microstructural damage through T1w/T2w ratio: a multicentre study. Issue 7 (17th May 2022)

• Record Type: Journal Article
• Authors: Margoni, Monica; Pagani, Elisabetta; Meani, Alessandro; Storelli, Loredana; Mesaros, Sarlota; Drulovic, Jelena; Barkhof, Frederik; Vrenken, Hugo; Strijbis, Eva; Gallo, Antonio; Bisecco, Alvino; Pareto, Deborah; Sastre-Garriga, Jaume; Ciccarelli, Olga; Yiannakas, Marios; Palace, Jacqueline; Preziosa, Paolo; Rocca, Maria A; Filippi, Massimo
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 93:Issue 7(2022)
• Page Start: 741
• Page End: 752
• Publication Date: 2022-05-17
• Subjects: multiple sclerosis -- MRI -- T1w/T2w-ratio; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2022-328908
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objectives: To evaluate white matter and grey matter T1-weighted (w)/T2w ratio (T1w/T2w ratio) in healthy controls and patients with multiple sclerosis, and its association with clinical disability. Methods: In this cross-sectional study, 270 healthy controls and 434 patients with multiple sclerosis were retrospectively selected from 7 European sites. T1w/T2w ratio was obtained from brain T2w and T1w scans after intensity calibration using eyes and temporal muscle. Results: In healthy controls, T1w/T2w ratio increased until 50–60 years both in white and grey matter. Compared with healthy controls, T1w/T2w ratio was significantly lower in white matter lesions of all multiple sclerosis phenotypes, and in normal-appearing white matter and cortex of patients with relapsing-remitting and secondary progressive multiple sclerosis (p≤0.026), but it was significantly higher in the striatum and pallidum of patients with relapsing-remitting, secondary progressive and primary progressive multiple sclerosis (p≤0.042). In relapse-onset multiple sclerosis, T1w/T2w ratio was significantly lower in white matter lesions and normal-appearing white matter already at Expanded Disability Status Scale (EDSS) <3.0 and in the cortex only for EDSS ≥3.0 (p≤0.023). Conversely, T1w/T2w ratio was significantly higher in the striatum and pallidum for EDSS ≥4.0 (p≤0.005). In primary progressive multiple sclerosis, striatum and pallidum showed significantly higher T1w/T2w ratio beyond EDSS=6.0 (p≤0.001). In multiple sclerosis, longer disease duration, higher EDSS, higher brain lesional volume and lower normalised brain volume were associated with lower lesional and cortical T1w/T2w ratio and a higher T1w/T2w ratio in the striatum and pallidum (β from −1.168 to 0.286, p≤0.040). Conclusions: T1w/T2w ratio may represent a clinically relevant marker sensitive to demyelination, neurodegeneration and iron accumulation occurring at the different multiple sclerosis phases.