Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study. Issue 7 (18th July 2022)

• Record Type: Journal Article
• Authors: Cao, Guiying; Long, Hai; Liang, Yuedong; Liu, Jue; Xie, Xiaoxin; Fu, Yanhua; He, Juan; Song, Su; Liu, Siqi; Zhang, Manna; Wu, Yu; Wang, Yaping; Du, Min; Jing, Wenzhan; Yuan, Jie; Liu, Min
• Is Part Of: BMJ open. Volume 12:Issue 7(2022)
• Publication Date: 2022-07-18
• Subjects: anaemia -- HIV & AIDS -- haematology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-059316
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: To estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART). Design: A cross-sectional study. Setting: PLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021. Participants: A total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study. Primary and secondary outcome measures: Anaemia was diagnosed as a haemoglobin concentration <120 g/L for non-pregnant females and <130 g/L for males. Mild, moderate and severe anaemia were diagnosed as below the gender‐specific lower limit of normal but ≥110 g/L, 80–110 g/L and <80 g/L, respectively. Results: The prevalence of anaemia was 27.5%, and that of mild, moderate and severe anaemia was 9.2%, 12.2% and 6.1%, respectively. Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. Widowed or divorced inpatients (anaemia: aOR=1.26, 95% CI: 1.08 to 1.47; severe anaemia: aOR=1.52, 95% CI: 1.16 to 1.97) and thrombocytopenia inpatients (anaemia: aOR=4.25, 95% CI: 3.54 to 5.10; severe anaemia: aOR=4.16, 95% CI: 3.24 to 5.35) had increased odds of anaemia and severe anaemia compared with their counterparts. Hepatitis C was associated with increased odds of severe anaemia (aOR=1.80, 95% CI: 1.11 to 2.92). Conclusions: Anaemia was prevalent among hospitalised PLHIV. Female sex, those widowed or divorced, and thrombocytopenia were associated with increased odds of anaemia, and those widowed or divorced, thrombocytopenia and hepatitis C were associated with increased odds of severe anaemia. Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression.