Ultrasound Assisted Formation of the Stable Form of Glycine and Its Mechanism. Issue 7 (11th April 2022)

• Record Type: Journal Article
• Authors: Jiang, Yujie; Song, Yujie; Su, Min
• Is Part Of: Crystal research and technology. Volume 57:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-11
• Subjects: cooling crystallization -- glycine -- polymorph -- stable -- ultrasound; Crystallography -- Periodicals; 548
• DOI: 10.1002/crat.202100137
• Languages: English
• ISSNs: 0232-1300

Abstract

Abstract: Ultrasound is a useful method to obtain the stable form for polymorph systems. The stable crystal form of glycine as a model compound in cooling crystallization using ultrasound is studied. The form of the crystal products is characterized by powder X‐ray diffraction. The influences of ultrasound process parameters, including the ultrasound treating timing, treating mode, power density and duration, on the γ‐glycine in cooling crystallization are conducted. The nucleation moment when a "critical size of cluster" is formed is the most effective moment for the ultrasound treatment, and at the same time produces more stable form. Pulse treating mode can effectively solve the ultrasound thermal effect problem. The total energy input and duration has a peak value in promoting the form transformation in practice. The mechanism of the ultrasound in promoting the stable form formation is also discussed. Abstract : To obtain the stable from γ‐glycine, the sono‐crystallization process of glycine is systematically discussed, and the mechanism of ultrasound in improving the formation process of the stable from γ‐glycine is discussed. The nucleation moment when a "critical size of cluster" is formed is the most effective moment for the ultrasound treatment, and at the same time produces more stable form. Ultrasound promotes directly the formation of stable γ‐glycine crystals.