Full left/full right liver graft ex situ split during hypothermic oxygenated perfusion. (18th April 2022)

• Record Type: Journal Article
• Authors: Rossignol, Guillaume; Muller, Xavier; Mohkam, Kayvan; Dubois, Remi; Lesurtel, Mickaël; Mabrut, Jean‐Yves
• Is Part Of: Pediatric transplantation. Volume 26:Number 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-18
• Subjects: machine perfusion -- organ preservation -- split liver transplantation; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.14284
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: Background: Ex vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to split grafts being considered as marginal is the prolonged static cold storage time related to ex vivo liver splitting. End ischemic hypothermic oxygenated perfusion is a validated strategy to improve outcomes of marginal whole grafts and may thus also benefit split liver grafts. Method: We present the first case of full left/full right split procedure performed during hypothermic oxygenated perfusion. Results: We present a standardized surgical two‐step approach where parenchymal transection was performed during end ischemic hypothermic oxygenated perfusion via the portal vein to shorten static cold storage duration. Both split grafts were successfully transplanted in a 4‐year‐old pediatric and a 38‐year‐old adult recipient. Despite high‐risk procedure (retransplantation), extended donor criteria including a prolonged cardiac arrest and high donor risk index (2, 25), both grafts showed early recovery of hepatic function and low serum transaminase release. At 6 months, both recipients were alive with a normal liver biology and a functioning graft. Conclusion: Although challenging, full left/full right liver split procedure during end ischemic hypothermic oxygenated perfusion can be successfully performed and is a promising strategy to improve post‐transplant outcomes.