Bienzymatic Spiky Janus Nanomotors Powered by Histamine. Issue 7 (10th June 2022)

• Record Type: Journal Article
• Authors: Fu, Dongmei; Ye, Yicheng; Gao, Chao; Xie, Dazhi; Peng, Fei
• Is Part Of: ChemNanoMat. Volume 8:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-10
• Subjects: nanomotors -- enzymatic -- histamine -- diamine oxidase -- Janus; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.202200152
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: As an important inflammatory mediator, histamine can be produced by many immune cells (mast cells, neutrophils, dendritic cells, platelets, etc.) and modulates a variety of immune events. Developing enzymatic micro/nanomotors from the perspective of immunometabolism is required but still lacking. In this work, we functionalized the histamine‐metabolizing enzyme onto the Janus Au/mSiO2 nanoparticles. Powered by the tandem catalytic decomposition of histamine initiated by a surface‐modified diamine oxidase, this nanomotor system exhibits an enhanced diffusive motion with increasing histamine concentration. At a concentration of histamine (500 mM), the motor speed reaches 9.25±1.71 μm.s −1, which is 2.3 times that of Brownian motion, and the corresponding diffusion coefficient is enhanced by 137%. This novel enzymatic nanomotor system not only expands the physiologic enzyme library for biomedical micro/nanomotors but also provides new ideas for the immune therapy of diseases targeting histamine. Abstract : Covalent conjugation of the enzyme diamine oxidase and catalase to spiky Janus Au/mSiO2 nanoparticles enables the tandem catalytic conversion of histamine and hydrogen peroxides generated in situ to power self‐driving nanomotors. This novel enzymatic nanomotor system developed from immunometabolism not only expands the physiologic enzyme library for enzymatic micro/nanomotors but also provides ideas for the therapy of diseases targeting histamine.