Fatty Acid Composition of Proximal Femur Bone Marrow Adipose Tissue in Subjects With Systemic Lupus Erythematous Using 3 T Magnetic Resonance Spectroscopy. Issue 2 (29th December 2021)

• Record Type: Journal Article
• Authors: Martel, Dimitri; Saxena, Amit; Belmont, Howard Michael; Honig, Stephen; Chang, Gregory
• Is Part Of: Journal of magnetic resonance imaging. Volume 56:Issue 2(2022)
• Page Start: 618
• Page End: 624
• Publication Date: 2021-12-29
• Subjects: systemic lupus erythematous -- femur -- bone marrow -- 3T MRI -- magnetic resonance spectroscopy -- glucocorticoids; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.28038
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: Systemic lupus erythematosus (SLE) is a chronic, inflammatory disease with common musculoskeletal manifestations, notably reductions in bone quality. Bone marrow adipose tissue composition and quantity has been previously linked to bone quality and may play a role in SLE pathophysiology but has not been thoroughly studied. Purpose: To use magnetic resonance spectroscopy (MRS) to investigate bone marrow adipose tissue quantity and composition in proximal femur subregions of untreated SLE patients compared to controls and treated patients. Study Type: Prospective. Subjects: A total of 64 female subjects: 28 SLE, 15 glucocorticoid (GC)‐treated SLE and 21 matched controls. Field Strength/Sequence: Stimulated echo acquisition mode (STEAM) sequence at 3 T. Assessment: MRS was performed at multiple echo times in the femoral neck and trochanter regions and fatty acids (FA) composition was computed. Statistical Tests: Intergroup comparisons were carried out using ANOVA. A P value < 0.05 was considered statistically significant. Results: SLE patients had significantly higher saturated FA compared to controls in both the femoral neck (+0.12) and trochanter (+0.11), significantly lower monounsaturated FA in the trochanter compared to controls (−0.05), and significantly lower polyunsaturated FA in the femoral neck compared to both controls (−0.07) and SLE patients on GC therapy (−0.05). Data Conclusion: SLE patients have altered proximal femur marrow fat metabolism, which may reflect a manifestation of, or play a role in, the altered inflammatory response of these patients. Evidence Level: 2 Technical Efficacy: Stage 2