Evaluation of serum levels of 8-oxo-2′-deoxyguanosine as a prognostic factor in nonmetastatic breast cancer patients. (May 2017)

• Record Type: Journal Article
• Authors: Shandiz, Fatemeh Homaei; Ghaffarzadegan, Kamran; Fariman, Saeed Jahani; Akbarzadeh, Mahdi; Elyasi, Sepideh; Mohammadpour, Amir Hooshang
• Is Part Of: Breast cancer management. Volume 6:Number 2(2017)
• Page Start: 71
• Page End: 79
• Publication Date: 2017-05
• Subjects: breast cancer -- 8-OxodG -- prognostic factor; Breast -- Cancer -- Periodicals; Breast -- Cancer -- Treatment -- Periodicals; 616.9944905
• DOI: 10.2217/bmt-2017-0009
• Languages: English
• ISSNs: 1758-1923

Abstract

Aim: 8-OxodG protein has been introduced recently as a new biomarker for breast cancer, according to its role in tumor progression and invasion. In this study, we investigated prognostic value of 8-Oxo-2′-deoxyguanosine (8-OxodG) protein in nonmetastatic breast cancer patients excluding confounding factor.Materials & methods: Before any adjuvant chemotherapy or surgery, serum level of 8-OxodG protein was determined in 79 patients with nonmetastatic breast cancer. All patients follow up for 5 years regarding cancer recurrence and survival.Results: Cumulative risk of recurrence 5 years after the beginning of the study was 0.86 and there was no significant correlation between 8-OxodG and the recurrence rate (p = 0.78).Conclusion: The serum levels of 8-OxodG protein may not be an appropriate prognostic factor in breast cancer.