Diaphragmatic plication among lung transplant patients: A single‐center experience. Issue 7 (3rd May 2022)

• Record Type: Journal Article
• Authors: Lawrence, Adrian; Lovin, Dylan; Mohanka, Manish R.; Joerns, John; Bollineni, Srinivas; Kaza, Vaidehi; Torres, Fernando; Murala, John; Peltz, Matthias; Wait, Michael A.; Banga, Amit
• Is Part Of: Clinical transplantation. Volume 36:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-03
• Subjects: diaphragmatic dysfunction -- outcomes -- phrenic nerve dysfunction -- restriction; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14683
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: There is lack of data reporting outcomes among patients needing diaphragmatic plication (DP) during or after lung transplantation (LT). We sought to assess the association of DP with post‐transplant spirometry among other outcomes. Methods: We included all patients who underwent LT between 2012 and 2016 ( n = 324, mean age 56.3±13.4 years; M:F 198:126). We compared early and late outcomes based on the need for DP. Results: The frequency of diaphragmatic dysfunction (DD) on pre‐transplant fluoroscopy was 52.2%. A total of 38 DP procedures were performed among 37 patients (11.4% of LT patients). DP was done for anatomic (sizing or spacing issues) or functional indications (symptomatic DD). While patients with DP had significantly lower spirometry throughout the 3‐year follow‐up period, their slope of decline, functional assessments at the first annual visit, the risk of CLAD, and mortality were similar to patients without DP. A sub‐group analysis limited to patients with restrictive lung diseases as the transplant indication had similar findings. Conclusions: Pre‐transplant DD is common among LT candidates although it did not predict the need for DP. DP may be performed for functional or anatomic indications especially for addressing the donor‐recipient size mismatch. Despite the lack of favorable effect on post‐transplant spirometry, patients undergoing DP have acceptable and comparable early and late outcomes.