Plasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals. (8th May 2018)

• Record Type: Journal Article
• Authors: Rosa, Daniela V; Magno, Luiz A; Pereira, Nathália CM; Romanelli, Luiz C; Albuquerque, Maicon R; Martins, Marina L; de Freitas Carneiro Proietti, Anna B; Nicolato, Rodrigo; Simões e Silva, Ana C; de Miranda, Debora M
• Is Part Of: Biomarkers in medicine. Volume 12:Number 5(2018)
• Page Start: 447
• Page End: 454
• Publication Date: 2018-05-08
• Subjects: antigens and antibodies -- cerebrospinal fluid -- HAM/TSP -- HTLV -- immune markers -- ITAC -- myopathy -- neurological symptoms -- plasma; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2017-0313
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses.Materials & methods: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms.Results: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms.Conclusion: Different cytokines' expression profile in the presence of neurological symptoms may help to understand and characterize the progression for severe clinical presentations.