Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome. (March 2018)

• Record Type: Journal Article
• Authors: Wang, Xiao; Wang, Yufeng; Cai, Zechuan; Lu, Xiaoxia; Li, Zhenxing; Chen, Yun; Zu, Guoliang; Li, Taoping
• Is Part Of: Biomarkers in medicine. Volume 12:Number 3(2018)
• Page Start: 217
• Page End: 228
• Publication Date: 2018-03
• Subjects: continuous positive airway pressure -- immunity -- inflammation -- metabolism -- obstructive sleep apnea hypopnea syndrome; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2017-0099
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS).Materials & methods: After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. In addition, the effects of 1-month continuous positive airway pressure (CPAP) were studied in moderate/severe OSAHS.Results: C3, serum total complement activity, superoxide dismutase, uric acid were significantly higher in moderate/severe OSAHS than that in no/mild OSAHS. In contrast, IGF-1 in moderate/severe OSAHS was lower than it in no/mild OSAHS, which was negative correlated with apnea-hypopnea index. Moreover, CPAP significantly decreased C3, meanwhile elevated IGF-1.Conclusion: C3, serum total complement activity and superoxide dismutase were higher in moderate/severe OSAHS, while IGF-1 decreased. Elevated C3 and reduced IGF-1 in moderate/severe OSAHS may be reversed by CPAP.