Myxoma versus myxoid liposarcoma involving the kidneys. Issue 3 (3rd July 2019)

• Record Type: Journal Article
• Authors: Findeis, Sarah K.; Salicru, Mauricio N.; Agarwal, Atin
• Is Part Of: Proceedings. Volume 32:Issue 3(2019)
• Page Start: 402
• Page End: 404
• Publication Date: 2019-07-03
• Subjects: CHOP -- DDIT3 -- myxoid mass -- myxoma of the kidney -- renal myxoma -- well-differentiated myxoid liposarcoma; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2019.1613328
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: Myxoid lesions of the kidney are rare. We present a case of a 74-year-old man who presented with an 8.5 × 8.0 × 6.0 cm left kidney mass that was grossly confined to the kidney and had a gelatinous cut surface. Histology of the tumor showed bland spindle cells in a myxoid stroma with interspersed thin-walled vessels. The tumor was negative for smooth muscle actin, desmin, CD34 (highlighted vessels), S100, and HMB-45 by immunohistochemistry. There was focal, nonspecific staining of MDM2 and CDK4. The lesion appeared more vascular than would be expected for a classic myxoma and, therefore, fluorescence in situ hybridization was performed for the 12q13 ( DDIT3 or CHOP ) rearrangement to rule out myxoid liposarcoma and the result was negative for a rearrangement. This case highlights the difficulty of delineating a primary myxoma of the kidney from a well-differentiated myxoid liposarcoma.