Approach to the diagnosis and treatment of non-tuberculous mycobacterial disease. (August 2021)

• Record Type: Journal Article
• Authors: Pennington, Kelly M.; Vu, Ann; Challener, Douglas; Rivera, Christina G.; Shweta, F.N.U.; Zeuli, John D.; Temesgen, Zelalem
• Is Part Of: Journal of clinical tuberculosis and other mycobacterial diseases. Volume 24(2021)
• Publication Date: 2021-08
• Subjects: ADR adverse drug reactions -- AFB acid fast bacilli -- AST antimicrobial-susceptibility testing -- ATS American Thoracic Society -- BCG Bacille Calmette-Guerin -- CLSI Clinical and Laboratory Standards Institute -- COPD chronic obstructive pulmonary disease -- ECG electrocardiogram -- EMB ethambutol -- Erm erythromycin ribosomal methylase -- FDA Food and Drug Administration -- HIV human immunodeficiency virus -- HRCT high resolution computed tomography -- IDSA Infectious Disease Society of America -- INF-γ interferon- γ -- INH isoniazid -- MAC Mycobacterium avium complex -- MIC minimum inhibitory concentrations -- MALDI-TOF matrix-assisted laser desorption ionization time-of-flight mass spectrometry -- MGIT mycobacteria growth indicator tube -- NTM non-tuberculous mycobacteria -- PCR polymerase chain reaction -- PFT pulmonary function test -- TB tuberculosis -- TDM therapeutic drug monitoring; Non-tuberculous mycobacteria -- Mycobacterium avium -- Mycobacterium abscessus; Tuberculosis -- Periodicals; Mycobacterial diseases -- Periodicals; 616.995
• DOI: 10.1016/j.jctube.2021.100244
• Languages: English
• ISSNs: 2405-5794

Abstract

Abstract: Non-tuberculous mycobacteria (NTM) is a collective name given to a group of more than 190 species of Mycobacterium . The clinical presentation for most NTM infections is non-specific, often resulting in delayed diagnosis. Further complicating matters is that NTM organisms can be difficult to isolate. Medications used to treat NTM infection can be difficult for patients to tolerate, and prolonged courses of anti-mycobacterial therapy are often required for adequate suppression or eradication. Herein, we review different NTM syndromes, appropriate diagnostic tests, and treatment regimens.