Intestinal aging is alleviated by uridine via regulating inflammation and oxidative stress in vivo and in vitro. Issue 14 (18th July 2022)

• Record Type: Journal Article
• Authors: Jiang, Na; Zhao, Zhiwei
• Is Part Of: Cell cycle. Volume 21:Issue 14(2022)
• Page Start: 1519
• Page End: 1531
• Publication Date: 2022-07-18
• Subjects: Uridine -- aging -- intestinal tract -- inflammation; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2022.2055252
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: Many countries in the world are stepping into the aging society with the challenge of the increasing agin gpopulation. The physiological functions of the human body begins to decline with aging, and the intestinal tract as the most important digestive organ will also be aging. How to relieve or reverse aging is an important scientific problem.The aging model in vivo and in vitro was established. Western-blot, indirect immunofluorescence and immunohistochemistry were carried out to explore the anti-aging effect of uridine.In the current study, we examined the anti-aging effect of uridine in vivo and in vitro experiments. In vitro cell model, we found that the aging level of intestinal tract was significantly reduced by uridine, uridine treatment down-regulated the Sa-β-gal-positive cells. Furthermore, the levels of inflammation and oxidative stress were also significantly reduced by uridine treatment. On this basis, in vivo experiments, we found that the aging level of mice fed with uridine was significantly lower than that of the control group as demonstrated by immunohistochemistry and Western blot analyses.In conclusion, our current research indicates that uridine shows a good anti-aging effect, which suggests that uridine is expected to be used as a health food or clinical drug to treat intestinal aging.